Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma.
نویسندگان
چکیده
منابع مشابه
Epidermal growth factor and transforming growth factor alpha.
This review describes the discovery and initial characterization of the epidermal growth factors (EGFs) and transforming growth factors alpha (TGF alpha), the biosynthesis and tissue distribution of these molecules and a brief description of the effects of these molecules in culture and animals. An analysis of the similarities between the EGFs and TGF alpha s from different organisms is used to...
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Intra-abdominal carcinomatosis after prophylactic oophorectomy in ovarian-cancer-prone families. Lancet 1982;2:795–7. (18) Struewing JP, Watson P, Easton DF, Ponder BA, Lynch HT, Tucker MA. Prophylactic oophorectomy in inherited breast/ovarian cancer families. J Natl Cancer Inst Monogr 1995;17:33–5. (19) Kemp GM, Hsiu JG, Andrews MC. Papillary peritoneal carcinomatosis after prophylactic oophor...
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EGFR is a key molecule in cancer cells. EGFR signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. We extracted proteins from astrocytoma (III and IV) oligodendroglioma(IV) tumors and normal brain tissues and then evaluated the protein purity by Bradford test ...
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Objective(s): Our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([125I]PYK) is promising for the evaluation of the epidermal growth factor receptor (EGFR) status and prediction of gefitinib treatment of non-small cell lung cancer. EGFR is over-expressed and mutated also in glioblastoma. In the present study, the ...
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The epidermal growth factor (EGF) receptor mediates the induction of a transformed phenotype in normal rat kidney (NRK) cells by transforming growth factors (TGFs). The ability of EGF and its analogue TGF-alpha to induce the transformed phenotype in NRK cells is greatly potentiated by TGF-beta, a polypeptide that does not interact directly with binding sites for EGF or TGF-alpha. Our evidence i...
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ژورنال
عنوان ژورنال: Gut
سال: 1994
ISSN: 0017-5749
DOI: 10.1136/gut.35.10.1468